4 things to know about melanoma vaccine MedTwitter
A cancer vaccine based on the messenger RNA technology, provided alongside the checkpoint inhibitor pembrolizumab , has shown encouraging results in an open label phase 2b clinical trial. The trial found that the combination regimen reduced the risk of cancer recurrence or death among melanoma patients by 44% compared with pembrolizumab alone,Here are four things to know about the mRNA-4157/V940 cancer vaccine and what the company has in store for upcoming clinical trials.
To identify a patient's specific mutations, researchers sequence DNA from the patient's normal tissue as well as DNA from the tumor. Results are compared to identify a set of mutations unique to the patient's cancer. Researchers then develop a single synthetic mRNA coding for up to 34 neoantigens, designed based on the tumor's specific mutational signature. The aim is for mRNA-4157/V940 to help the patient's immune system identify and attack the tumor cells only.
By itself,"the RNA sequencing takes only 2 hours to develop, which is just mind-boggling that it can happen so quickly," Holen said."It's important to do this quickly because patients with cancer don't have much time to wait." After acquiring samples from patients, sequencing, running the algorithm to identify specific mutations, manufacturing the RNA, and delivering the vaccine to patients take about 6 weeks in total.Serious treatment-related events occurred in 14.4% of patients who received the combination of mRNA-4157/V940 and pembrolizumab vs 10% receiving pembrolizumab monotherapy.
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