Researchers at Cold Spring Harbor Laboratory (CSHL) have identified a new drug target for Ewing sarcoma, a rare form of cancer typically diagnosed in children and young adults. Their experiments reveal that the cells responsible for this cancer can be effectively reprogrammed with the flick of a gen
Scientists discovered targeting a protein called ETV6 can turn Ewing sarcoma cancer cells back to normal-looking and -behaving connective tissue cells, as seen above. Credit: Vakoc lab/Cold Spring Harbor Laboratoryhave identified a new drug target for Ewing sarcoma, a rare form of cancer typically diagnosed in children and young adults. Their experiments reveal that the cells responsible for this cancer can be effectively reprogrammed with the flick of a genetic switch.
Ewing sarcoma causes tumors to grow in bones or the soft tissues surrounding them. Once a tumor begins to spread to other parts of the body, it can be very difficult to halt the disease’s progression. Even for patients with positive outcomes, treating Ewing sarcoma often causes toxic side effects. New treatments are badly needed, says CSHL Professor Christopher Vakoc, who led the research on ETV6.
Vakoc and his colleagues became excited about ETV6 when their experiments revealed that Ewing sarcoma cells seem uniquely dependent on this protein. “This protein is present in all cells. But when you perturb the protein, most normal cells don’t care,” he says. “The process by which the sarcoma forms turns this ETV6 molecule—this relatively innocuous, harmless protein that isn’t doing very much—into something that’s now controlling a life-death decision of the tumor cell.
Norge Siste Nytt, Norge Overskrifter
Similar News:Du kan også lese nyheter som ligner på denne som vi har samlet inn fra andre nyhetskilder.
Slowing, Not Stopping, Alzheimer's a Better Goal for Drug Trials?Slowing progression of, rather than stopping, Alzheimersdisease has measurable benefits for patients and families and may be a more realistic goal for clinical AD drug trials, a new report suggests.
Les mer »
Oppo matches Samsung on years of software support for the Find N2 FlipOppo is matching Samsung in the years it will support major and security updates for its Find N2 Flip
Les mer »
Probable Risk Genes Linked to ADHD in Large StudyThis international genome-wide study of ADHD — the largest to date — identified 27 genetic risk variants that influence ADHD and shed light on the genetic underpinnings of ADHD and its comorbidities.
Les mer »
Nick Frost, Alicia Silverstone, Kevin Connolly to Lead Dark Comedy 'Krazy House'Nick Frost, Alicia Silverstone, and Kevin Connolly will lead dark comedy 'Krazy House.'
Les mer »
Controversial route switch for U.S. 380 bypass brings residents to McKinney TxDOT meetingTxDOT holds meeting about U.S. 380 bypass
Les mer »
The 2023 Chevy Colorado Has No Physical Light SwitchIf you want to turn off the lights, you'll have to hit a virtual button in the infotainment system.
Les mer »