The second booster drops the risk from exceedingly small to … even smaller. But is that enough for the U.S. to launch another ambitious round of immunizations?
“For the majority of healthy younger adults, I don’t believe a fourth vaccine makes sense,” said Dr. Warner Greene of the Gladstone Institutes in San Francisco. “Three doses provides strong protection from hospitalization and death — these are the numbers that count, not the number of infections.”
“A threefold drop sounds like a lot, and so the decision to take a remarkably safe booster may feel like a slam-dunk,” said infectious disease expert Dr. Bob Wachter, chair of UC San Francisco Department of Internal Medicine.The fourth shot reduced the odds of severe illness in high-risk Israelis from about 1 in 21,936 to 1 in 75,460.
In a January statement, WHO asserted that “a vaccination strategy based on repeated booster doses of the original vaccine composition is unlikely to be appropriate or sustainable.” But for the rest of us, repeated booster doses of our existing vaccines offer only diminishing returns in terms of protection against future strains, Greene said.
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