A study in the Neurology journal suggests that the diabetes drug pioglitazone may reduce dementia risk in newly diagnosed type 2 diabetics, with benefits amplified in those with a history of ischemic heart disease or stroke. However, the drug's potential side effects call for further research into i
Recent research suggests a potential link between the diabetes drug pioglitazone and a reduced risk of dementia in people with newly diagnosed type 2 diabetes. The study, led by Dr. Eosu Kim from Yonsei University, analyzed data from 91,218 participants over an average of 10 years, showing that those taking pioglitazone were 16% less likely to develop dementia. This percentage rose to 37% in those taking the drug for four years.
“Since dementia develops for years before diagnosis, there may be an opportunity for intervening before it progresses,” said study author Eosu Kim, MD, PhD, ofin Seoul, Republic of Korea. “These results may suggest that we could use a personalized approach to preventing dementia in people with diabetes in the case that they have a history of ischemic heart disease or stroke.”
During the study, 8.3% of the people taking pioglitazone developed dementia, compared to 10.0% of those who were not taking the drug. After researchers accounted for other factors that could affect dementia risk, such as high blood pressure, smoking and physical activity, they found that people taking pioglitazone were 16% less likely to develop the disease than those who did not take it.
“These results provide valuable information on who could potentially benefit from pioglitazone use for prevention of dementia,” Kim said. “In some previous studies of people with dementia or at risk of cognitive decline who did not have diabetes, pioglitazone did not show any protection against dementia, so it’s likely that a critical factor affecting the effectiveness is the presence of diabetes. More research is needed to confirm these findings.
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