Case Western Reserve University biochemical researchers have identified a new function of a key protein that leads to cancer—a finding they believe could lead to more effective treatments for a range of cancers and other diseases.
Scientists have also identified in recent years that the overexpression of LSD1—in this instance, producing too many proteins—can drive development of cancer and heart disease.
And some researchers have recently looked to slow cancer growth by stopping the catalytic activity of LSDI—the chemical reaction that spursBut Kaixiang Cao, an assistant professor of biochemistry, is leading a team that challenges that assumption: The medical school researchers argue that they can achieve far greater success to slow or stop cancer growth in
by instead degrading the entire LSD1 protein, not merely short-circuiting the chemical reaction that leads to its overexpression.Their research was published in August in"We need a really precise and effective way of targeting these proteins, and our research shows that stopping that catalysis might be effective 15% of the time, while our approach is closer to 80%," Cao said.
Cao said he and his team were surprised LSD1 functions mainly in a catalytic-independent manner, but now that they've provided to thea"theoretical foundation that this is going to be a more effective way to treat these diseases," they'll begin to test further, first in cancerous tissues, then animal models and eventually human trials.
"This is the future—you add the degrader, and it will kill the protein completely," he said."The technique is already there because it has been done to other proteins by other researchers—but not yet to LSD1."Cheng Zeng et al, Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition,
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