Experiments suggest that SARS-CoV-2 infections after vaccination trigger antibody levels similar to those in people whose infections preceded their vaccination.
against the SARS-CoV-2 spike protein, one of the immune system’s main targets when it is fending off the virus. These individuals’ blood serum — which contains antibodies — blocks a diverse array of SARS-CoV-2 variants, and does so more effectively than serum from vaccinated people who were never infected and serum from people whose immunity comes from infection only.
Microbiologist Fikadu Tafesse at Oregon Health & Science University in Portland and his colleagues analysed serum from three groups of health-care workers: some who’d had breakthrough infections, others who’d been infected before they were vaccinated, and vaccinated people with no history of infection. In laboratory assays, the sera from both groups with previous infections had higher levels of antibodies against the spike protein than did serum from people protected only by vaccines.
, although the team has not yet looked at activity against Omicron. The researchers report their work in a 25 January study in
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