Breast cancer racial disparity linked to DNA repair gene expression

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Breast cancer racial disparity linked to DNA repair gene expression
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A difference in how genes involved in DNA repair are expressed may help to explain why Black women in the US have a higher mortality from breast cancer than white women

Expression of DNA repair genes in some Black women may be linked to higher breast cancer mortality ratesBlack women in the US have a higher mortality rate from breast cancer than white women. This may be in part due to differences in how a person’s environment affects the expression of genes involved in DNA repair.

“Oestrogen receptor positive cancer is the most common type of breast cancer diagnosed in the world,” says Haricharan. “Based on estimates, it accounts for about 60 to 80 per cent of breast cancer.”more likely to die from this type of cancer than white women. Structural racism, socioeconomics and lifestyle all play a role in this disparity, says Haricharan, but it is also important to study differences in molecular biology.

Haricharan believes that overlooking these differences when treating people can have real consequences. “Precision medicine today is based on white people,” she says. “And I think people who come from other backgrounds, other races, other ethnicities – who might have different molecular signals – we’re not taking that into account.”

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