A UCLA study discovered potential broad-spectrum antiviral agents capable of combating various RNA virus families, including those causing future pandemics. Particularly effective were cyclic dinucleotide (CDN) STING agonists, which showed therapeutic promise against the Chikungunya virus and other
Researchers have discovered potential wide-ranging antiviral agents that can combat multiple RNA virus families, including those that may cause future pandemics. The study identified several promising antivirals, with the most effective being cyclic dinucleotide STING agonists, which have also shown potential in cancer immunotherapy.
A new study has identified potential broad-spectrum antiviral agents that can target multiple families of RNA viruses that continue to pose a significant threat for future pandemics. The study, led by Gustavo Garcia Jr.
“A robust host antiviral response induced by a single dose treatment of STING agonist cAIMP is effective in preventing and mitigating the debilitating viral arthritis caused by Chikungunya virus in a mouse model. This is a very promising treatment modality as Chikungunya virus-affected individuals suffer from viral arthritis years and decades from the initial infection,” Arumugaswami added.
“The study of transcriptional changes in host cells reveals that cAIMP treatment rescues cells from the harmful effect of CHIKV-induced dysregulation of cell repair, immune, and metabolic pathways,” Ramaiah added.
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