Deactivation of the gene PLa2g7 partially mimics the anti-aging effects of caloric restriction (CR) in mice, researchers report in Science. The findings could be used to develop CR-mimetic targets to enhance health span and potentially lifespan in humans.
Moderately decreased food intake that does not cause malnutrition has beneficial effects on health span and life span in model organisms. Spadaro. examined measures of immune function in humans who restricted caloric intake by about 14% over 2 years and in mice under a more severe 40% restriction . Cellular analyses and transcriptional surveys showed marks of improved thymic function under caloric restriction.
Thus, decreased expression ofThe extension of life span driven by 40% caloric restriction in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically relevant CR-mimetic targets. We report that about 14% CR for 2 years in healthy humans improved thymopoiesis and was correlated with mobilization of intrathymic ectopic lipid.
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