A high expression of the enzyme beta1,4-galactosyltransferase-3, or B4GALT3 is associated with noticeably shortened survival rates in several types of immunotherapy cancersdeficiency in mice TIME inhibits tumor growth.
The study shows that a significant reduction of glycosylation -- a type of protein modification -- on T cell surfaces correlates with increases in CD8+ immune cells infiltrating tumors. Weakly immunogenic and strongly immunogenic tumor cells were subcutaneously transplanted into B4GALT3 knockout and wild-type mice, to examine for tumor cell growth. Only the knockout mice suppressed the growth of strongly immunogenic tumor cells.An old campaign slogan for cough syrup,"It tastes awful.
Heng Wei, Chie Naruse, Daisuke Takakura, Kazushi Sugihara, Xuchi Pan, Aki Ikeda, Nana Kawasaki, Masahide Asano. An experimental drug enhanced the benefit of an immunotherapy to fight pancreatic cancer in mice by increasing the number of immune cells in the immediate vicinity of the tumor, leading to a ...
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