A new SciImmunology study in mice explains how the immune system’s first responders, known as neutrophils, find their way to lymphnodes for disposal after skin infections are resolved. Read more ➡
Neutrophil recruitment to the draining lymph node is a crucial step in various skin-related immune responses; however, the mechanism by which this occurs is unclear. Here, Özcanused various skin inflammation and infection models to track the movement of neutrophils homing to and leaving the skin. They found that the skin neutrophils migrated to the skin-draining lymph nodes in a CCR7-mediated manner.
Here, we found that neutrophil responses in inflamed or infected skin were regulated by CCR7-dependent migration and phagocytosis of neutrophils in draining lymph nodes . In mouse models of Toll-like receptor–induced skin inflammation and cutaneousinfection, neutrophils migrated from the skin to the dLNs via lymphatic vessels in a CCR7-mediated manner. In the dLNs, these neutrophils were phagocytosed by lymph node–resident type 1 and type 2 conventional dendritic cells.
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