The CDC's call for those at risk to get up to date on their vaccines comes after a cluster of at least 21 mpox cases was reported in Chicago.
Three new reports released by the CDC and the New England Journal of Medicine Thursday demonstrated that two shots of the Jynneos vaccine provide more protection than a single dose.
Though the estimates of mpox vaccine effectiveness vary, Daskalakis said the message is clear: "One dose is good, two doses are better." A subcutaneous injection is administered under the skin, while an intradermal shot is injected between the layers of the skin. The intradermal shots use less vaccine substance, which allows public health authorities to stretch the vaccine supply.
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