Choline, a crucial nutrient produced in the liver and present in foods such as eggs, broccoli, beans, meat, and poultry, is vital to human health. A new study finds that deficiency in dietary choline can negatively impact the body and could play a role in the development of Alzheimer’s disease. M
Choline is an essential nutrient that is vital for human health. It plays a role in producing acetylcholine, a neurotransmitter involved in memory, muscle control, and mood. Choline also helps build cell membranes and regulate gene expression.
Further, the study illustrates that choline deficiency in mice causes significant weight gain, and alterations in glucose metabolism, , and deficits in motor skills. The research highlights a constellation of physical and neurological changes linked to choline deficiency. Sufficient choline in the diet reduces levels of the aminohomocysteine, which has been recognized as a neurotoxin contributing to neurodegeneration and is important for mediating functions such as learning and memory, through the production of acetylcholine.
Velazquez is joined on the study by co-lead authors Nikhil Dave and Jessica Judd. The work is highly interdisciplinary, including researchers from the ASU Biosciences Mass spectrometry facility, and the Translational Cardiovascular Research Center at the University of Arizona College of Medicine in Phoenix, AZ.
Alzheimer’s disease is the leading cause of dementia and the fifth leading cause of death among Americans aged 65 and older. Today, Alzheimer’s affects 6.5 million in the U.S. alone and is projected to strike close to 14 million Americans by 2060. By this time, the costs of managing Alzheimer’s are expected to exceed $20 trillion, threatening the healthcare infrastructure while causing immense suffering.
The first outward symptoms of the disease are usually related to language, memory, and thinking problems, as brain regions associated with these tasks tend to be among the first affected. Yet researchers now know that by the time the disease causes observable symptoms, it has been quietly ravaging the brain for 20 years or more.
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