Nature research paper: Combination anti-HIV antibodies provide sustained virological suppression
MethodsThe purpose of this clinical trial was to assess the safety, tolerability and virological efficacy of a combination of two bNAbs 3BNC117 and 10-1074 in individuals with HIV. The study consisted of two components: a randomized, double-blind, placebo-controlled trial and an open-label, single-arm trial .
The study participants in group 1 were randomized to receive multiple infusions of 3BNC117 and 10-1074 or placebo during the 24-week period. One study participant whose regimen contained a non-nucleoside reverse transcriptase inhibitor was switched to an integrase inhibitor-based regimen 2 weeks before ATI due to the long half-life of NNRTIs. The study participants in group 1 discontinued ART 3 days after the first infusion of 3BNC117 and 10-1074 or placebo.
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