In a new study, researchers at the University of Missouri have created a proof of concept of a nanocapsule—a microscopic container—capable of delivering a specific 'payload' to a targeted location.
While beyond the scope of this study, the discovery could one day impact how drugs, nutrients and other types of chemical compounds are delivered within humans or plants. The power of the forward-thinking idea for this tiny delivery mechanism comes from its inventive structure, said Gary Baker, an associate professor in the Department of Chemistry and study co-author.
"We have the ability to uniformly prepare nanocapsules in a cookie-cutter fashion by joining them together using calcium metal ions asor linking logs," Baker said."By doing this, we can generate multiple identical reservoirs which can transport different types of substances, or payloads. Additionally, we have proof that the substances within can transfer through the barrier of these nanocapsules into an external solution.
"The combination of countless substructures interacting with a surface provides solid footing for the gecko. In much the same way, these nanocapsules are held together by a multiplicity of weak chemical interactions, but when added up together they provide aThe study represents an important step forward for the field of supramolecular chemistry, said Jerry Atwood, a Curators' Distinguished Professor Emeritus of Chemistry and internationally recognized leader in the field.
Kanishka Sikligar, a postdoctoral fellow at MU, made the discovery. Sikligar, who came to MU to study with Atwood, was surprised by the team's finding. "The size of these nanocapsules pushes well beyond the boundary of what's been previously achieved by other researchers in this area," Sikligar said."I am excited to see how this discovery will help expand the knowledge and understanding of this field."Kanishka Sikligar et al, Nanocapsules of unprecedented internal volume seamed by calcium ions,
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