New lab studies suggest SARSCoV2 causes brain cells to stick together, but more research is needed to determine the overall significance.
. Now, researchers have shown that SARS-CoV-2 can cause brain cells to fuse together, disrupting their communication. Although the study was only done in cells in a lab dish, some scientists say it could help explain one of the pandemic’s most confounding symptoms.
Researchers already knew that SARS-CoV-2 could cause certain cells to fuse together. The lungs of patients who die from severe COVID-19 are oftenwhich scientists believe may contribute to the respiratory symptoms of the disease. Like other viruses, SARS-CoV-2 may incite cells to fuse to help it spread across an organ without having to infect new cells.
However, the neuronal syncytia seen in the lab dishes and organoids also had some peculiarities that made them stand out from those seen in lungs. When lung cells fused, only the main parts of the cell body connected to each other. Among neurons, in contrast, the fusion happened farther away from the cell body, at long, thin extensions known as dendrites and axons, which are critical for cell-cell communication.
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