A recent study found that the way cerebellar neurons communicate with other brain regions is different in various movement disorders.
The cerebellum is a region of the brain that helps us refine our movements and learn new motor skills. Patients and mouse models experience many kinds of abnormal movements when their cerebellum is damaged. They can have uncoordinated and unbalanced movements, called ataxia. They can have atypical positioning of body parts or uncontrolled movements because their muscles are working against each other, called dystonia. Or they can have disruptive shaky movements, called tremors.
"We performed further studies with other disease models to test whether different genetic or drug-induced origins of abnormal movements influenced the disease code. Importantly, we found that -- irrespective of the disease origin -- the abnormal features of the neural signals in mice with similar movement disorders were the same.
The team then used these different light patterns to change the cerebellar neural code of healthy mice to test if they could create disease behaviors on demand as the mice freely moved around in a box."When we induced the activity patterns associated with ataxia, our healthy mice immediately exhibited ataxic movements. The same mice displayed dystonic movements with the dystonia-associated pattern and developed tremor when they were given the tremor-associated pattern." Dr.
For more than a century, scientists have known that while the commands that initiate movement come from the brain, the neurons that control locomotion once movement is underway reside within the ...
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