Recent patents relating to CRISPR methods and compositions for gene editing and therapeutic use
A CRISPR nanocomplex for nonviral genome editing and a method for preparing the same. The nanocomplex has a size of several nanometers to several micrometers, enabling intracellular delivery without external physical stimulation, and can be utilized for genome editing through nonviral routes with respect to target genes in cells.CRISPR–Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit or modify a target RNA.
Board of Trustees of Southern Illinois University , The Royal Institution for the Advancement of Learning/McGill University A method of treating a subject having a retroviral infection by administering a therapeutically effective amount of a composition comprising a vector encoding a CRISPR-associated endonuclease and at least two guide RNAs, wherein the guide RNAs are complementary to two target sequences spanning from the 5′ to 3′ LTRs of the sequence in the retrovirus, thereby eradicating...
A means to modulate gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knockout or knock-in strategies and strategies that provide for correction or alteration of single nucleotides.
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