Deep sleep may function as a buffer against cognitive decline in older adults with Alzheimers disease pathology by protecting cognitive reserve, new research suggests.
Studying resilience to existing brain pathology is"an exciting new research direction," lead author Zsófia Zavecz, PhD, with the Center for Human Sleep Science at Cal Berkeley, told"That is, what factors explain the individual differences in cognitive function despite the same level of brain pathology, and how do some people with significant pathology have largely preserved memory?" she added.
The findings remained significant after adjusting for age, sex, BMI, gray matter atrophy, and previously identified cognitive reserve factors, such as education and physical activity.One is that during deep sleep specifically, memories are replayed in the brain, and this results in a"neural reorganization" that helps stabilize the memory and make it more permanent.
"More work is needed in a larger population before we can fully leverage this stage of sleep to reduce the risk of developing cognitive decline," Griffin told, Shaheen Lakhan, MD, PhD, a neurologist and researcher in Boston, said, the study is"exciting on two fronts — we may have an additional marker for the development of Alzheimer's disease to predict risk and track disease, but also targets for early intervention with sleep architecture–enhancing therapies, be they drug,...
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