Q&A with Fauci on masking, vaccines, and what keeps him up at night
. We've made extraordinary progress over the 38 years that I've been director of the institute We have a vaccine, though it isn't a perfect vaccine [for malaria]; we have monoclonal antibodies that are now highly effective in preventing malaria; we have newer drugs, better drugs for tuberculosis, but we don't have an effective vaccine for tuberculosis. So, malaria vaccines, tuberculosis vaccines, those are all unfinished business. I believe we will get there.
Ever since Omicron came well over a year ago, we have had sublineages of Omicron that progressively seem to elude the immune response that's been developed. But the one thing that's good and has been sustained is that protection against severity of disease seems to hold out pretty well.
Yes, we certainly want next-generation vaccines – both vaccines that have a greater degree of breadth, namely covering multiple variants, as well as a greater degree of duration. So, the real question is,"Is it the mRNA vaccine platform that is inducing a response that is not durable, or is the response against coronaviruses not a durable response?" That's still uncertain.
When you're in a situation like that, even if it's a crowded congregant setting, I don't have any problem not wearing a mask. But when I'm unsure of what the status is and I might be in an area where there is a considerable degree of viral activity, I would wear a mask. I think you just have to use [your] judgment, depending on the circumstances that you find yourself in.
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