In our latest News and Views, Joel Ernst and Paul Ogongo discuss how single-cell, longitudinal analyses can help inform vaccine development for TB MakOgongo_3 UCSF
proteome includes nine other peptides in other PE proteins with >80% sequence similarity to this epitope, which prompts the question: might protection be a consequence of cross-recognition of multiple PE13-related proteins expressed by? CFP-10 is notable for its deletion from the existing BCG TB vaccine, and it is secreted as a heterodimer with ESAT-6, which is implicated invirulence. Thus, it stands to reason that CFP-10 would be a valuable vaccine antigen.
It is especially noteworthy that the authors identified an epitope recognized by T cell clonotypes enriched in TB progressors, potentially reflecting a ‘bad’ antigen. This epitope is from. The apparently opposite effects of T cell recognition of CFP-10 and EspA highlights the challenges of empirically choosing antigens and emphasizes the need for further systematic analyses incorporating T cell phenotypes, epitopes and TB outcomes.
The authors’ finding that a large majority of TCR similarity clusters are found with equal frequencies in TB controllers and TB progressors implies thatexpresses numerous antigens and epitopes that induce T cells with little impact on TB outcomes — and are therefore useless in the context of infection or vaccine responses.
Norge Siste Nytt, Norge Overskrifter
Similar News:Du kan også lese nyheter som ligner på denne som vi har samlet inn fra andre nyhetskilder.
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection - Nature MedicineAnalysis of peripheral mycobacteria-reactive CD4+ T cell receptor sequences from individuals infected with Mycobacterium tuberculosis shows a high degree of overlap between progressors and controllers, but points to some distinct clonotypes that are enriched in either group.
Les mer »
Academia’s lost luster prompts exodus of health researchers to industry - Nature MedicineA desire for better work conditions and real-world impact are behind the movement, which may hinder academic clinical trials while leading to beneficial collaborations.
Les mer »
Year in Review | Nature Medicine2022 saw major leaps forward in transplant research, from the first pig-to-human heart transplant to the partial revival of pig organs after death. Check out this and our other Notable Advances of the year here:
Les mer »
Disruptions to the hearing health sector - Nature MedicineTechnological innovation and changes to regulation are disrupting the hearing health sector, with implications for data privacy, product safety and accessibility, and provide challenges and opportunities for equitable hearing health.
Les mer »
OpenAI now valued at $29 billion in prospective sale of private sharesThe creator of ChatGPT and DALL-E may raise over $300 million.
Les mer »
Penn Medicine has been awarded a nearly $10 million grant to educate genetic counselorsDaily News | Penn Medicine has been awarded a nearly $10 million grant to educate genetic counselors
Les mer »