Researchers at the Cincinnati Children’s/UC Medical Center Proton Therapy Center are conducting a first-in-human trial of a radiation treatment that they say holds promise in treating tough to kill tumors.
“So, a treatment that might typically take a minute would be delivered in a half a second. That can even further spare some of the normal tissue from the effects of radiation,” Dr. Breneman explains.
Because FLASH proton therapy is being tested in a clinical trial, the current participants must be adults, but researchers are hoping the findings of this trial will allow them to expand. “One research question is, will FLASH be able to help us cure kids with D.I.P.G. or other tumors that we can’t cure right now?,” said Pediatric Oncologist at the Cincinnati Children’s Hospital, John Perentesis, MD.
After having traditional proton therapy and chemo, Kelly Murphy was able to ring the chimes, signaling the end of treatment, and now 18, he’s cancer-free. Preclinical trials in animals suggested that the FLASH proton therapy could safely deliver treatment with fewer side effects, but prior to the University of Cincinnati trial, it had never been tested in humans. The trial focused on patients with bone cancer in their limbs. Researchers say the next human trial is enrolling adult patients with bone cancers that are closer to the lungs and hearts.
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