FGF21 will not be on a pharmacy shelf anytime soon, but could help treat alcohol poisoning in the future.
, a team of researchers found that FGF21 actually plays an even broader role in defending mice against the harmful consequences of ethanol exposure. It stimulated arousal from intoxication without actually changing the breakdown of ethanol in the mice’s body.
“We’ve discovered that the liver is not only involved in metabolizing alcohol but that it also sends a hormonal signal to the brain to protect against the harmful effects of intoxication, including both loss of consciousness and coordination,” said study co-author and biochemist Steven Kliewer of the University of Texas Southwestern Medical Center,
. “We’ve further shown that by increasing FGF21 concentrations even higher by injection, we can dramatically accelerate recovery from intoxication. FGF21 does this by activating a very specific part of the brain that controls alertness.” FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system. CREDIT: Cell Metabolism/Choi et al.
The team gave mice whose livers procured normal amounts of FGF21 an intoxicating dose of ethanol and then injected more FGF21. The added hormones helped the mice recover their coordination more quickly and took half as long to wake up as the mice who didn’t get the extra dose.–which corrects the body’s position when it is not in a normal upright position.
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