Gene deletion behind anomaly in blood cancer cells uwmedicine CellStemCell
Although this structural change inside blood cells indicates possible cancer, until a recent study, no one knew what caused it to happen., cancer biologists report the discovery of the genetic mutation behind this cell abnormality.
What determines the fate of these progenitor cells that causes the emergence of cancerous cells, rather than normal neutrophils? While they are still in their multipotent state and able to give rise to any one of a variety of blood cell categories, the progenitor cells for neutrophils, redMyeloid cells themselves can sometimes show abnormal, precancerous changes. The researchers on this recent study were able to cast suspicion on the loss of nuclear lamin B1, encoded on chromosome 5q.
His group went on to detail that lamin B1 deficiency alters genome organization. This in turn caused expansion of the blood-forming stem cells, a bias towards their becoming myeloids, genome instability due to defective DNA damage repair and other problems that set the stage for cancer.
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