Nature research paper: Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes
D.L.L. and C.N.L. are named inventors on a US provisional patent application that describes GSDMA activities.thanks Dario Zamboni and the other, anonymous, reviewer for their contribution to the peer review of this work.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations., Cytotoxicity of HEK293Ts transfected with human GSDMs ± SpeB. Data are the mean±s.d. of 4 technical replicates.
, mouse GSDMA_1 , mouse GSDMA_2 , mouse GSDMA_3 aligned with Clustal Omega algorithm in DNASTAR. Disordered solvent accessible loop . Inverted arrows identify cleavage sites of SpeB on hGSDMA. Residues 240–247 of hGSDMA are identified ., Keratinocytes were infected with GAS 5448, isogenic mutant controls, or clinical isolates for 4 h and lysis measured by LDH release and SpeB activity measured using specific substrate Mca-IFFDTWDNE-Lys-Dnp.
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