Some (spooky?) science for your Halloween: What makes us feel 'fight or flight' may be less adrenaline and more of something else—a hormone that seeps out of our bones. 💀
The findings led Karsenty to hypothesize that animals evolved bony skeletons to escape danger.
Next, Karsenty's group set out to determine whether osteocalcin is required to trigger fight-or-flight mode, an involuntary physical reaction to threat. The mode includes a racing pulse, heavier breathing, and a spike in blood sugar; the response provides the body extra fuel for a speedy escape. When the team put mice genetically engineered not to make osteocalcin through the same stressors as the nonengineered mice, the rodents barely reacted.
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