Short-term and cyclical use of estrogen and progestin therapy for menopausal symptoms is linked to an increased risk of dementia, results of a large, observational study show. HRT MedTwitter
were published online June 28 inBefore WHIMS was published in 2003, HRT was widely prescribed to relieve menopausal symptoms. However, WHIMS, which included more than 4000 women aged 65 years or older, revealed that HRT was associated with a twofold increased risk of dementia.
To discover whether age of initiation or length of duration of HRT affects health outcomes, Pourhadi and his team undertook the observational study. The registry records showed that nearly 5600 women developed dementia and 56,000 did not develop dementia. Of the 5600 women with dementia, 1460 had a diagnosis of AD.
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