If someone was recently infected with a BA.2 lineage, are they mostly protected against reinfection with BA.4 or BA.5? Probably not, infectious disease experts say.
Adalja said it essentially comes down to the number and type of mutations in the receptor binding domain of the spike protein. There's an "abundance" of important mutations, he said, which doesn't bode well for protection against reinfection.
It's unlikely that someone who was recently infected by a BA.2 lineage will be reinfected with that lineage, Lawler said. "Those antibody studies seem to be pretty consistent. We don't have great correlation of immunity between antibody levels and protection, but as a general rule, studies have shown that high titers of neutralizing antibodies generally predict higher levels of protection.
"It depends on the variant," he said. Protection against reinfection "would be expected to be months if there are no immune-evasive changes. Now, it's probably a matter of weeks to a month."
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