The human body is cloaked in skin, a protective layer that shields our insides from external threats.
of the eye's optical power. To preserve this vision, immune responses such as inflammation must be tightly controlled in the cornea., Mueller and colleagues suspected that many of the cornea's resident immune cells were actually T cells. They had seen how these T cells protected against eye infections in mice and wondered if the same was true in humans., which allows researchers to visualize living tissue at cellular levels and track their movements in time-lapse videos .
Imaging healthy human corneas in 16 young adults revealed T cells jostling about on high alert, interacting with dendritic cells and nerves in the cornea's outermost layer, the corneal epithelium.confocal microscopy is a non-invasive imaging technique used to visualize cells in the cornea's three main tissue layers .
"Imaging deeper into the corneal stroma, we show that crawling macrophages and rare motile T cells patrol the tissue," the teamThe findings expand our understanding of the types of immune cells residing in the cornea, protecting us from pathogens, and the researchers also showed how T cells specifically respond to different stimuli.
The team captured how the eye's immune cells responded to short-term contact lens wear and in individuals with"Because this new technique involves non-invasive, time-lapse imaging of the human cornea, [it] could be used in clinics directly to assess immune responses and ocular health,"Of course, the technique will need further validation before clinical use.
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