This is good news for couples battling infertility, especially those who have had unsuccessful IVF treatments.
A novel drug named OXO-001 has demonstrated promising results in boosting embryo implantation success rates during in vitro fertilization , perhaps leading to a considerable rise in live births.“We are thrilled with the results of this trial, which highlight OXO-001’s potential to become the first therapeutic treatment to increase embryo implantation success, with a non-hormonal drug using a new mechanism of action, acting directly on the endometrium,” said Dr.
Unlike other fertility drugs that use hormones, OXO-001 works directly on the lining of the womb, making it more receptive to the implanted embryo. While the exact mechanism of OXO-001 remains undisclosed by Oxolife, the company suggests it influences the production of specific molecules crucial for embryo implantation. These molecules help the embryo adhere to the womb’s lining, preventing it from moving and facilitating successful implantation.OXO-001’s efficacy was evaluated in a Phase 2 clinical trial conducted across 28 centers in Europe. They were divided into two groups: 42 received a placebo, while 54 took a daily dose of OXO-001.
The results were promising. The group taking the oral drug showed significantly higher pregnancy rates compared to the placebo group . This included higher rates of “biochemical pregnancy,” detectable heartbeat at 10 weeks, and ultimately, live births. “Despite continuous developments in ovarian stimulation, embryo manipulation and culture, improving live birthrates in medically assisted reproduction has been incremental at best. A jump of nearly 7% is very good news for our patients, and hopefully this can be confirmed in larger patient groups,” said Prof Karen Sermon, chair of the European Society of Human Reproduction and EmbryologyFurther study is going to corroborate these findings in bigger trials.
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