The desensitizing drug ketamine helped more people overcome treatment-resistant depression symptoms than electroconvulsive therapy, according to a new study.
May 30, 2023 – The desensitizing drug ketamine helped more people overcome treatment-resistant depression symptoms than electroconvulsive therapy, according to a new study.
Ketamine causes a psychedelic effect called disassociation and has been shown in previous studies to have a rapid impact on depression symptoms. ECT therapy passes small electric currents through the brain and triggers a short seizure, and it's believed to change brain chemistry linked to mental health.
“ECT has been the gold standard for treating severe depression for over 80 years,” said researcher Amit Anand, MD, a psychiatrist at Mass General Brigham and a professor at Harvard Medical School, in a. “But it is also a controversial treatment because it can cause memory loss, requires anesthesia, and is associated with social stigma. This is the largest study comparing ketamine and ECT treatments for depression that has ever been done, and the only one that also measured impacts to memory.
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