A new study shows an association between longer telomere length and healthier brain structures and lower risk for dementia in older adults. NeuroTwitter
Telomere shortening — a sign of cellular aging — is associated with multiple changes in the brain associated with dementia, whereas longer telomeres associate with better brain health and lower risk for dementia, new research suggests.
The mechanism underlying this risk is unclear and may involve changes in brain structure and function. However, the relationship between telomere length and neuroimaging markers is poorly characterized. They found that longer leucocyte telomere length was associated with a larger volume of global and subcortical grey matter and a larger hippocampus — both of which shrink in patients with AD. Longer telomeres were also associated with a thicker cerebral cortex, which thins as AD progresses.Topiwala noted that many of the factors related to telomere shortening, such as age, genetics, and sex, can't be changed.
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