Nature highlights three key graphics from the week in science and research.
It was hoped that a new breed of COVID-19 vaccine — based on Omicron variants of the virus SARS-CoV-2 — would offer substantially greater protection than older vaccines that are based on the strain of the virus that emerged in 2019. But ansuggests that updated boosters offer much the same level of protection as does an extra dose of the older vaccines. The study is a preprint that has not yet been peer reviewed.
The team’s modelling showed that, in a population where half of people are already protected against a symptomatic SARS-CoV-2 infection through previous vaccination or infection, an updated vaccine booster bumped protection up to 90%, compared with 86% protection provided by an extra dose of the original vaccine. For protection against severe disease, however, the difference in protection was less than 1%.
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Political commentators, media hosts give Biden's campaign style speech mixed reviews: 'Divisive by nature'Journalists and media hosts gave President Biden some mixed reviews on his Philadelphia speech that hammered 'MAGA Republicans' as threats to democracy.
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Momentum-selective orbital hybridisation - Nature CommunicationsWhen a molecule interacts chemically with a metal, its orbitals hybridise with metal states to form the new eigenstates of the coupled system. Here, the authors show that in addition to overlap in real space and energy, hybridizing states must fulfil a momentum-matching condition.
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Automated reconstruction of whole-embryo cell lineages by learning from sparse annotations - Nature BiotechnologyAutomated reconstruction of whole-embryo cell lineages by learning from sparse annotations
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Long-term cardiac pathology in individuals with mild initial COVID-19 illness - Nature MedicineIn individuals with long-term cardiac symptoms after an initially mild course of COVID-19 illness, magnetic resonance imaging and measurement of cardiac injury biomarkers commonly detected ongoing cardiac inflammation but not structural heart disease.
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MVsim is a toolset for quantifying and designing multivalent interactions - Nature CommunicationsArising through multiple binding elements, multivalency can specify the avidity, duration, cooperativity, and selectivity of biomolecular interactions, but quantitative prediction and design of these properties has remained challenging. Here the authors enable facile analysis and engineering of multivalent binding by developing MVsim, a simulator that incorporates biochemical and biophysical parameters of interacting molecules and is accessible through a graphical user interface.
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