A retrospective analysis shows no difference in major adverse cardiovascular events (MACE) between TNF inhibitors, IL-17 inhibitors, IL-23 inhibitors, and IL-12/IL-23 inhibitors.
Rates of major adverse cardiovascular events do not differ significantly among individual biologics used for psoriasis or psoriatic arthritis , a database analysis finds. Data from the TriNetX health records database included 32,758 patients treated with TNF inhibitors , interleukin-17 inhibitors , IL-23i , and IL-12i/IL-23i .
The researchers calculated time-dependent risk for MACE using multinomial Cox proportional hazard ratios. The reference was TNFi exposure.Compared with TNFi use, there was no difference in the incidence of MACE events in the IL-17i, IL-23i, or IL-12i/IL-23i group. There were also no significant differences between biologic groups in the incidence of congestive heart failure, myocardial infarction, or cerebral vascular accident/stroke.Despite some concern about increased risk for MACE with TNFi use, this study suggests no special risk for patients with psoriasis or PsA associated with TNFi vs other biologics.
Psoriatic Arthritis Arthropathic Psoriasis Psoriatic Arthropathy Psa Arthritis Joint Inflammation Biologic Therapy Biologics Wisconsin Heart Failure Congestive Heart Failure Congestive Cardiac Failure CV Risk Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors Cardiovascular Risk Management Cardiovascular Disease Cvd - Cardiovascular Disease Cox Cyclooxygenase
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