In what may be the first estimate of bacterial deaths worldwide, researchers reported 33 bacterial pathogens were responsible for more than 1 in 7 deaths in 2019, with five pathogens linked to slightly more than half of those deaths.
, and peritoneal and intra-abdominal infections. The syndromes responsible for the most deaths varied across locations.
"There was substantial variation in which pathogen was the most dominant across different infectious syndromes," the authors note, withbeing the leading cause of fatal bloodstream infections , and andThere was"considerable variation" by region in the burden of bacterial infections, with the greatest number of deaths occurring in sub-Saharan Africa,"where we clearly saw the effect of both Gram-positive and Gram-negative pathogens," they write.
"By estimating mortality and YLLs for a broad range of pathogens and infectious syndromes, we have produced a global account of bacteria for which the burden was previously unknown and, perhaps, underappreciated," they note.Of the five most clinically significant pathogens they identified, onlyhas been the focus of global surveillance and public health initiatives, they wrote, with the others"not a major focus of any global public health initiatives.
"The main principles to combat bacterial drug-resistant infections have been clearly defined and agreed upon…However, their implementation has proven much harder," wrote editorialist Dolecek and colleagues.
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