A technique called surface-enhanced Raman spectroscopy can detect tiny quantities of compounds in solution, but has been difficult to use for quantitative analysis. A digital approach involving nanoparticles suggests a way forward. A technique for measuring trace quantities of molecules in water.
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser . In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.Detecting trace quantities of substances in complex aqueous media, such as river water, sewage and treated drinking water, can be like looking for the proverbial needle in a haystack.
Numerous sensitive methods have been developed, but they often rely on complicated sample-processing and signal-acquisition steps, and are typically time consuming and costly. An approach known as surface-enhanced Raman spectroscopy can detect single moleculesand has long been promoted as a promising alternative to such methods. But SERS is a notoriously finicky technique, with intrinsic variabilities, which makes it hard to use to quantify low concentrations of dissolved compounds.
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