In a phase 2 study, enoblituzumab - a humanized Fc-engineered B7-H3–targeting antibody - was safe and showed preliminary evidence of potential clinical activity in men with high-risk ProstateCancer DocEShenderov HopkinsMedicine
) Total unique T-cell clonotypes expanded in tumor or peripheral blood at prostatectomy versus fraction of peripheral clones expanded and detected intratumorally. Each point on the scatter plots represents a patient. Blue dots indicate responders for a given outcome and red dots indicate non-responders.
Genes that remained significant after Benjamini and Yekutieli False Discovery Rate are in blue and labeled. Matched 1:1 untreated controls by grade group, stage, margins, block age [within 2 years], age [within 2 years], and self-reported race. Tumor regions isolated by macrodissection. Extended Data Fig. 6 Grouped boxplots of difference in mean log2 marker level of upregulated proteins by clinical outcome using DSP of the TME in pretreatment biopsies and post-treatment prostatectomies following B7-H3 monoclonal antibody treatment., protein marker status by PSA response at 12 months after prostatectomy versus PSA recurrence. Protein expression was assessed in n = 27 tissue samples from n = 32 patients .
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