A total of eight engineered phages were chosen, and a combination of four of these was found to be most effective against E. coli.
Antibiotic treatment has been shown to kill harmful bacteria in our gut and other healthy ones. This depletion of good bacteria may harm the health of people fighting diseases such as cancer.may have a negative impact on the body's overall microbiome and may even lead to antibiotic resistance in some cases.
To address these concerns, scientists at SNIPR BIOME company have been working on developing a targeted approach to kill harmful bacteria while saving the essential ones precisely., is currently in the clinical trials phase. It could be given to patients with hematological cancer in the future.explained: “Translocation of gut bacteria, including Escherichia coli, from the gastrointestinal tract is a frequent cause of bloodstream infections.
According to the study, nearly 162 phages were screened to find those capable of infecting a wide range of strains derived from humans. The strains were obtained from people who had bloodstream or urinary tract infections and from healthy people's guts.After this step, the phages were engineered using CRISPR to target the E. coli genome. A total of eight engineered phages were chosen, and a combination of four of these was found to be most effective againstThe drug was tested in mice models by administering it orally. The results showed that there was less E.
E. coli is responsible for many bacterial infections in cancer patients. It has also been discovered to resist fluoroquinolones, the antibiotics used to treat such infections.Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic resistance. To develop a phage therapy against a diverse range of clinically relevant Escherichia coli, we screened a library of 162 wild-type phages, identifying eight phages with broad coverage of E.
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