The efficacy and safety of JAK inhibitors for hair regrowth in adults with alopecia areata were reinforced by new results from clinical trials of two drugs presented at a late-breaker research session at AAD2023 DermTwitter
, according to King. In THRIVE-AA1, the primary endpoint of SALT ≤ 20% was reached by 29.6%, 41.5%, and 0.8% of the 8 mg, 12 mg, and placebo groups, respectively. Patient satisfaction scores, safety, and tolerability were also similar, according to King.
Providing an update on the BRAVE-AA program, Senna reported 104-week data that appear to support the idea of a life-changing benefit from JAK inhibitor therapy. This is because the effects appear durable. "The follow-up suggests that if you keep patients on treatment, you can get many of them to a meaningful response," she said.
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