The cells are responsible for cognitive decline.
It’s all because of the APOE4 gene expressed by microglia, one of the strongest genetic risk factors for Alzheimer’s disease that makes it so that the human brain cannot metabolize lipids normally. The end result is a build-up of excess lipids that interferes with neurons’ ability to communicate with each other.
The researchers now hope that if they can restore normal lipid metabolism in microglia, they may succeed in treating some of the symptoms of the disease. So far, it has been estimated that people who carry one copy of APOE4 have a threefold higher risk of developing Alzheimer’s, and people with two copies have a tenfold higher risk.“If you look at this another way, if you look at the entire Alzheimer's disease population, about 50 percent of them are APOE4 carriers.
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