Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these protein-RNA interactions.
The newfound ability to predict these interactions can help future work in understanding molecular pathways in the cell and pave the way for developing drugs targeting these RNA G-quadruplex binding proteins, that are found to be involved in disease such as cancer.
Proteins binding to RNA are important in many processes in the cell and can mediate a range of biological functions. A specialized structure in both DNA and RNA, the G-quadruplex, are regulatory elements involved in gene expression in both DNA and RNA. In the present work the researchers use theoretical predictions and molecular biology experiments to show that many chromatin-binding proteins bind to RNA G-quadruplexes.
Ulf Ørom's group has previously shown that RNA-DNA dual binding proteins are likely to have an involvement in the DNA damage response, linking DNA and RNA binding properties to a number of proteins. In the new study, the researchers expanded the knowledge of RNA-binding proteins to identify RNA G-quadruplex binding proteins.
With these new results, the researchers identify properties of protein-RNA interactions, and provide means to identify G-quadruplex binding properties that can potentially be targeted therapeutically in disease.The interplay between ribonucleic acid and proteins is not only important for maintaining cellular homeostasis but is also at the center of the tug-of-war between virus and host. Until now, ...
Genes Amyotrophic Lateral Sclerosis Cystic Fibrosis Cell Biology Biochemistry Research Molecular Biology Biology
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