Being overweight in midlife has been linked to greater risk of developing Alzheimer’s disease or dementia, and a new study shows that brain changes in obese people mirror some of those with Alzheimer’s.
To take a closer look at the impact of obesity on brain structure, Morys and his colleagues scrutinized brain scans from 341 Alzheimer’s patients and 341 obese individuals with a BMI of 30 or more, along with scans from 682 healthy individuals.
“The study showed that obese individuals and those with Alzheimer’s disease have common areas of the brain that are smaller in size, possibly due to a neurodegenerative process,” meaning that the nerve cells in these regions may be experiencing damage and could be dying, Diano said. “We do know that obesity is associated with other diseases that can affect the blood vessels in the brain, such as type 2 diabetes, high blood pressure, high cholesterol and inflammation, all of which could lead to the breakdown of blood vessels in the brain and thus contribute to brain cell death,” Malone said.
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