A phase 1 trial of the OncolyticVirus DNX-2401 followed by intravenous anti-PD-1 Pembrolizumab in patients w/recurrent Glioblastoma shows an encouraging clinical benefit rate & 12 months overall survival. gelarehzadeh FarshadNassiri
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations., changes in perilesional FLAIR signal hyperintensity at each study MRI time point for individual patients. Patients are colored according to their mRANO responses., changes in perilesional FLAIR signal hyperintensity at each study MRI time point relative to baseline MRI. Data presented are mean +/− 95%CI.
e, Heatmap showing three subtypes of glioblastoma microenvironment on previously published cohort examining adjuvant PD-1 monotherapy in recurrent glioblastoma.Distribution of scores for immune cell types , immune checkpoint genes and biomarkers , functional orientation markers and signature scores . Shown are boxplots for each TME subtype. Dots denote individual values. N = 38 independent patient samples in total.
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