Extended-release ketamine tablets taken twice weekly was effective for treatment-resistant depression with fewer side effects compared with intravenous or intranasal ketamine in a phase 2 trial.
In the trial, twice weekly dosing of extended-release ketamine led to statistically significant and clinically meaningful improvement in depressive symptoms.
Several small studies have shown that ketamine still works as an antidepressant when taken orally, although it still produces some dissociation. The study met its primary objective, with the 180-mg R-107 group demonstrating a significant reduction in MADRS scores compared with placebo (mean difference, -6.1;Seventy-one percent of patients in the placebo group experienced a relapse into depression after 13 weeks compared with 43% of patients who received twice weekly oral ketamine.
"In addition, the researchers demonstrated a major upside of oral ketamine — that side effects did not separate significantly from placebo," Keedwell said.
Adverse Effects Side Effects Antidepressant Antidepressant Drug Patient Safety Intravenous IV - Intravenous Intravenous Route Blood Intravenous Anesthetic Intravenous Anesthetic Agent Intravenous Anaesthetic Intravenous Anaesthetic Agent Increased Blood Pressure Sedation Sedative Sedative Use Anesthesia Anesthetic Anesthaesia Anaesthetic Anxiety Dizziness Fellowship
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