People who took the antiviral Paxlovid to treat COVID-19 infections were not more likely to get back-to-back bouts of the virus, a new study shows.
The findings offer clarity amid concerns that the use of Paxlovid, which works by stopping the spread of the virus in the body, increased the risk of COVID-19 rebound.
“Rebound is a re-emergence of symptoms and an uptick in viral load after a period of recovery,” the Center for Infectious Disease Research and Policy explained in aResearchers found that patients who received Paxlovid, another antiviral called Lagevrio, or no antiviral medication had rebounds at similar rates, ranging from 4.5% to 6.6%.and included 4,592 people in Hong Kong who were hospitalized within 3 days of a COVID diagnosis. The study period was from Feb.
The study further found that the risk of rebound was tied to being 18 to 65 years old , having chronic medical conditions, and receiving steroid treatment. Another finding, which the authors noted was important, was that it appeared Paxlovid did not make rebounds more severe. People who got Paxlovid and had a rebound infection were not more likely to be admitted to the intensive care unit, need a ventilator to help them breathe, or die.
“Surprisingly, the odds of viral burden rebound in patients receiving [Paxlovid] were significantly reduced in individuals who were not fully vaccinated,” he noted.in Rome, said the takeaway from the study is the importance of continuing to offer antivirals to people at high risk of developing severe COVID.Center for Infectious Disease Research and Policy: “COVID antivirals not tied to rebound or worse outcomes.
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