New nanoparticles that mimic the properties of platelets can support clot formation in human blood and alleviate bleeding disorders such as thrombocytopenia in rodents, according to a new study in ScienceTM. BloodDisorders
This work was supported by NIH grants R01 HL121212 to A.S.G.; R01 HL098217 to M.N.; R15 HL145573 to W.L.; R35 GM119526 to M.D.N.; F32 HL149207 to J.A.; VA grant A2611-R, A-3077, and IK6RX003077 to J.C.; and VA grant I01RX003420-01A1 to A.S. Y.K. was supported by a NIH NIBIB training grant T32EB004314 in the Department of Biomedical Engineering at Case Western Reserve University.
carried out in vivo studies evaluating PPNs in the mouse thrombocytopenia model and rat liver injury traumatic hemorrhage model. J.C. and A.S. supervised the immunohistochemistry studies and Y.K. carried out these studies in rat organs. J.A., S.H., and A.H. performed in vivo studies and data analysis in the mouse traumatic hemorrhage model. A.S.G. and U.D.S.S. wrote the manuscript.A.S.G.
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