Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors - Nature Biotechnology

Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors

labeled by their panels. The counts of peptides containing the indicated modification per haplotype are plotted against the counts of peptides containing unmodified amino acids. The Pearson correlation and p value for the correlation are indicated on each graph. Counts of N - Deamidation are more correlated to its mimic D - unmodified than its source amino acid . Counts of Q - Deamidation are more correlated to its mimic E - unmodified than its source amino acid .

Similarity score distribution for three types of PSM pairs: two PSMs event taken from the same synthetic peptide in the same sample run . We compared the PSM with the highest hyperscore to the PSM with the median hyperscore. A native PSM taken from HeLa digest standard proteomics compared to a matching synthetic spectrum . Similarity score between two randomly chosen PSMs .

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