Changes to primary endpoints in phase 3 cancer trials occur frequently and are often undisclosed in study manuscripts, new research shows.
Lack of transparency in randomized controlled trials remains a"pressing concern," despite efforts to make protocols available and require clinical trial registration. And it's unclear how often clinical trials report changes in primary endpoints.
Overall, the team found that 19% of trials underwent primary endpoint changes during the trial, but the rates of primary endpoint changes detected using the three methods varied considerably. The highest rate of changes was detected in published protocols , followed by ClinicalTrials.gov , and self-reported .
The most frequent primary endpoint changes involved reporting a primary endpoint as a secondary endpoint , making a change to the primary endpoint definition , and changing a secondary endpoint to a primary endpoint . Of 145 trials with primary endpoint changes, 61% were positive compared with only 51% without a primary endpoint change. In multivariable analysis, a primary endpoint change was independently associated with trial positivity .
Norge Siste Nytt, Norge Overskrifter
Similar News:Du kan også lese nyheter som ligner på denne som vi har samlet inn fra andre nyhetskilder.
ChatGPT accurately answers questions about common cancer myths, Huntsman study showsChatGPT is not always great at providing accurate answers, but there's at least one realm in which it far surpasses social media: common cancer myths.
Les mer »
MAP Center, Common Ground partner up for summer programMAP Youth Navigation will provide eight weeks of fun outdoor activities and enrichment for youth and teens.
Les mer »
Sweetener alert: the chemical in common sweeteners damages DNAScientists have discovered that a chemical formed during the digestion of a widely used sweetener is genotoxic, causing DNA damage.
Les mer »
National Black Bear Day recognizes most common bear in North AmericaIt's National Black Bear Day! We're bringing back the first bear sighting of 2023 and a link to video of a black bear taking a bath on Mount Lemmon from 2021.
Les mer »
Great white sharks more common off California coast than previously thought, study saysIf you have swum in the ocean off the coast of Santa Barbara or San Diego recently, chances are you swam next to a young great white shark.
Les mer »
“Genotoxic” Warning: Chemical Found in Common Sweetener Damages DNASucralose, a widely used artificial sweetener, produces a DNA-breaking compound, sucralose-6-acetate, during digestion, according to a recent study. This compound, also found in trace amounts in the sweetener itself, exceeds safe toxicological thresholds and can cause genotoxicity and 'leaky gut.'
Les mer »