A new study may help explain the mechanisms by which psilocybin can alleviate major depression, writes ckbergland
For their latest paper, first author Richard Daws, senior authors Carhart-Harris and Dunn, and their colleagues analyzed fMRI brain scans of 59 participants with TRD or MDD in two very different studies.
Participants in this study's"psilocybin arm" were given two 25 mg oral doses of psilocybin three weeks apart and took a daily-filled capsule for six weeks. Those in the"SSRI-arm" were given two 1 mg oral doses of psilocybin three weeks apart and ingested a 10-20 mg escitalopram capsule every day for six weeks. All participants had their brain network modularity and dynamic flexibility measured at baseline and after six weeks using fMRI neuroimaging.
Based on the findings of these two trials, the authors conclude:"Consistent efficacy-related brain changes, correlating with robust antidepressant effects across two studies, suggest an antidepressant mechanism for psilocybin therapy: global increases in brain network integration.
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