There is 'good evidence' that medications with principally noradrenergic action could be effectively repurposed for treating Alzheimer's disease.
The trials included a total of 1811 patients. Of these, six were judged as"good" quality, seven as"fair," and six as"poor."Pooled data from 10 trials with 1300 patients showed a significant small positive effect of noradrenergic drugs on global cognition, as measured by the Mini-Mental State Examination or Alzheimer's Disease Assessment Scale-Cognitive Subscale .
They are now conducting a trial testing the noradrenergic agent guanfacine in patients with AD, when taken in combination with established acetylcholine-boosting medications. "Looking in the research literature as was done in this study gives us clues as to directions that could be investigated further, and this paper opens the door for testing noradrenergic drugs in Alzheimer's clinical trials that employ the latest information we have in how studies should be designed," Snyder said.
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